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KMID : 0613820050150020287
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Journal of Life Science
2005 Volume.15 No. 2 p.287 ~ p.292
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Anti-inflammatory Activity of the Galactomannans Produced by a New Fungal Strain Trichoderma erinaceum DG-312
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Joo Ji-Hoon
Lim Jong-Min
Koo Kwang-Bon
Choi Jang-Won
Yun Jong-Won
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Abstract
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The crude galactomannans (GMs) were obtained from the culture of a newly isolated fungus Trichoderma erinaceum DG-312 and their anti-inflammatory activity was investigated in mice. The maximum concentrations of mycelial biomass and GMs reached 9.44 g/l, 2.72 g/l at day 3 in a 5-l stirred-tank bioreactor, respectively. The results of Sepharose CL-6B gel chromatography and compositional analysis revealed that the crude GMs contain heterogeneous polysaccharides consisting of 74.9% mannose and 24.1% galactose. The GMs was shown to possess a significant anti-inflammatory activity against acetic acid-induced inflammatory mouse model in a dose-dependent manner, when mice were treated with 100 and 200 ㎎ GMs/㎏ body weight. The inhibition in vascular permeability (60.6%) and in writhing response (62.5%) evidenced an anti-inflammatory activity of the GMs. The marked anti-inflammatory and writhing-lowering properties of the GMs suggest its potential therapeutic use.
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